Science

Co-founder and Chief Executive Officer

BioMarkIQ Scientific Technologies Pvt Ltd

Pune Inc: Winner of Startup India seed fund, this city enterprise seeks to enable early detection of lung cancerBiomarkIQ, incubated at IISER Pune, is creating a non-invasive tool by which vulnerable people can get tested.

'I Had 10 Ideas When I Quit My Job''When I was toying with 10 different ideas, my father was diagnosed with lung fibrosis and his condition deteriorated so badly that we lost him in six months. He was very unsatisfied with the lack of proper diagnosis.' 'It made me think will anyone do a biopsy if there is no symptom? Why is it that we do not have any non-invasive diagnostic method?' 'This idea was the strongest out of the ten, and with Snahlata Singh with her cancer biology background joining me, the idea got a real boost.'

Startup Mantra: Cancer diagnosis gets a biotech pushAI and ML-based VarSee is a non-invasive and sensitive tool that uses biotechnology to identify unique biomarkers of lung cancer

Co-founder and Chief Executive Officer at

BioMarkIQ Scientific Technologies Pvt Ltd

Think Science

Where kids learn to breathe science...

Curiosity is the basic characteristic of growing kids. They are curious about everything that surrounds them. Parents often try to satisfy their child’s satiety for knowledge by simply Googling for an answer or throwing in a Tell Me Why book. However, these measures just fill them with text and jargon, leaving the conceptual understanding far behind. Consequently, their queries come to a standstill. We, at Think Science, decided to come up with a quarterly science magazine designed exclusively to inculcate scientific thinking in school going children. Via “Think Science”, we aim to introduce them to fascinating world of science around us in a non-burdensome, engaging, enjoyable and pleasant form.

Publications

1. Ahmad,I., Kulkarni,M., Gopinath,A. and Saikrishnan,K. (2018) Single-site DNA cleavage by Type III restriction endonuclease requires a site-bound enzyme and a trans-acting enzyme that are ATPase-activated. Nucleic Acids Res., 46, 6229–6237.

2. Kulkarni,M., Nirwan,N., Van Aelst,K., Szczelkun,M.D. and Saikrishnan,K. (2016) Structural insights into DNA sequence recognition by Type ISP restriction-modification enzymes. Nucleic Acids Res., 44, 4396–4408.

3. Chand,M.K., Nirwan,N., Diffin,F.M., Van Aelst,K., Kulkarni,M., Pernstich,C., Szczelkun,M.D. and Saikrishnan,K. (2015) Translocation-coupled DNA cleavage by the Type ISP restriction-modification enzymes. Nat. Chem. Biol., 11, 870–877.

Biochemical, Bioinformatic and Crystallographic Analyses of Type III RM enzyme: EcoP1I

PhD Thesis

During my graduate studies at IISER, Pune, I worked with a special type of molecular scissors called EcoP1I and tried to dissect out its secrets.

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